Medicube PDRN vs Rejuran: Which PDRN Serum Is Worth It? (2026)

Rejuran is a brand and PDRN is the ingredient, which both Rejuran's Turnover Ampoule and Medicube's PDRN Pink Peptide Serum contain. On 24 Oct 2026, Medicube cost $0.80 per mL ($24 / 30 mL) and Rejuran $1.73 per mL ($52 / 30 mL)^2,6. Rejuran will refund an unopened bottle you do not want, while Medicube refunds only damaged or defective items^3,7.

Quick answer

• Pick Medicube if you want the lower price, $0.80 per mL on its site or $0.63 on Amazon^2,4; you want a vegan PDRN option, sold as Rose PDRN¹; you want the larger pool of buyer ratings, 25,746 on Amazon⁴.
• Pick Rejuran if you want a refund on an unopened bottle within 30 days⁷; you want an ingredient list with no added fragrance⁵; you want a subscription that cuts 12% and can be changed online^6,8.
• What they share: both are leave-on serums for daily use on the face. Neither brand states a PDRN amount on its own product page^1,5.

Medicube vs Rejuran at a glance

Notes. Prices from each store's product data^2,6. Per mL: $24 / 30 = $0.80; Amazon $18.90 / 30 = $0.63⁴; $52 / 30 = $1.73; $72 / 50 = $1.44. Sources and ingredients^1,5. Rejuran's 0.5% figure appears on its Amazon listing⁹. Use^1,5. Returns^3,7. Subscription^6,8. Ratings^4,5,9.

How we compared On 24 Oct 2026 we checked both product pages, store data, refund policies, Rejuran's FAQ, three Amazon listings and PubMed. We compared price per mL, label names and amounts, use, refund and subscription terms, and ratings with counts. Nobody at DermaRatings has used either product.

Price and what you get

Medicube sells one size, a 30 mL bottle at $24.00 on its own store². Both versions, Salmon DNA PDRN and Rose PDRN (Vegan), cost the same². That is $24 / 30 = $0.80 per mL. On Amazon the salmon version was $18.90, sold by "Medicube & Aprilskin"⁴. That is $18.90 / 30 = $0.63 per mL.

Rejuran sells the Turnover Ampoule in two sizes⁶. The 30 mL bottle costs $52.00, so $52 / 30 = $1.73 per mL. The 50 mL bottle costs $72.00, so $72 / 50 = $1.44 per mL. A subscription takes 12% off⁶. That makes the 30 mL $45.76 ($1.53 per mL) and the 50 mL $63.36 ($1.27 per mL).

Two catches apply. First, Rejuran's FAQ says each subscription shipment "must meet the free shipping minimum" to ship free⁸. The banner put that minimum at $50⁵. A subscribed 30 mL at $45.76 falls below it. Second, Amazon had a limited-time deal on the 30 mL at $41.57, which works out to $1.39 per mL⁹. Deals like that change often.

Rejuran's lowest own-site price is still $1.27 / $0.80 = 1.6 times Medicube's per mL. At full price it is $1.73 / $0.80 = 2.2 times.

Rejuran's Recover c-PDRN Lifting Ampoule costs $129 for 14 vials of 2 mL, or $129 / 28 = $4.61 per mL. It lists "Hydrolyzed DNA (7,000 ppm)" and is sold as "post-treatment care"¹¹.

How each one is used

Medicube says to "apply a generous amount morning and night on clean, dry skin"¹. Spread it over face and neck, then use moisturizer, plus sunscreen by day¹.

Rejuran says to apply 3 to 5 drops after cleansing and toning⁵. Massage it into the face, neck and décolletage, avoiding the eyes. It says to use it once or twice a day, and it can also go on the back of the hands⁵.

Ingredients

Medicube. The page names Salmon DNA PDRN, peptides and niacinamide as key ingredients¹. On the list, PDRN appears as Sodium DNA. The salmon version also lists Milt Extract and Salmon Egg Extract¹. The Rose PDRN version lists Rosa Damascena Extract instead¹. Both list five peptides, including Copper Tripeptide-1, and adenosine¹. The pink color comes from Cyanocobalamin, a form of vitamin B12¹.

One downside: the page does not agree with itself. Its "Formulated without" list names "Acrylates", "EDTA and derivatives", "Ethoxylated Ingredients" and "Fragrances"¹. Yet both ingredient lists include Fragrance, Disodium EDTA, Glycereth-26 and several acrylate polymers¹. If you avoid any of these, go by the ingredient list, not the claims list.

Rejuran. The page calls c-PDRN "a marine-based growth factor"⁵. On the list it appears as Hydrolyzed DNA, after niacinamide, licorice root extract and sodium hyaluronate^5,9. The list also has arbutin and adenosine, and phenoxyethanol and benzyl alcohol as preservatives⁹. No fragrance is listed⁹.

The page says "This formula contains the highest level of c-PDRN available"⁵. That is the brand's own claim, and its site gives no amount to check it against. Rejuran's Amazon listing says "Our patented c-PDRN formula (0.5% concentration)"⁹. For how to read numbers like that, see our PDRN serum percentage guide.

Subscription, returns and support

Medicube offers no subscription on this product page². Its refund policy covers only items that arrive damaged or defective: "we can assist with a refund or replacement within 30 days of purchase"³. You email photos to medicube_uscs@apr-in.com. Only orders from medicube.us qualify³. So if you simply do not like the serum, the brand store does not offer a refund. Amazon listed a "FREE 30-day refund/replacement" for its listing⁴.

Rejuran's store at rejuranusa.com redirects to rejurancosmetics.com, where its policy sits^5,7. It offers a refund if your purchase "does not meet your expectations within 30 days of the delivery date"⁷. But "all returned products must be in new, unopened condition"⁷. A $10 restocking fee comes off the refund, and so does the cost of the return label⁷. The fee is waived only for a confirmed defect. Opened products can come back only with proof of an allergic reaction, such as a medical note or photos⁷. Amazon orders are not covered by that policy, but Amazon showed its own 30-day refund on both Rejuran listings^7,9,10.

You change or stop a Rejuran subscription through an online settings link, per its FAQ⁸. Support is at support@rejuranusa.com⁵.

What buyers say

Medicube. On Amazon the serum had 4.6 stars from 25,746 ratings, with 83% five-star and 3% one-star⁴. Amazon's review summary counted 573 mentions of glow (528 positive) and 419 of hydration (399 positive)⁴. Value was mostly positive, 283 of 373 mentions. Skin irritation drew 243 mentions with mixed views, and some buyers reported breakouts⁴. Texture split opinion: 142 of 225 mentions called it non-greasy, and 83 did not⁴.

Rejuran. On Amazon the Turnover Ampoule had 4.5 stars from 1,311 ratings, with 78% five-star and 4% one-star⁹. Buyers praised hydration, 86 of 90 mentions, and skin texture, 59 of 63⁹. Views were split on effect: 70 of 101 mentions were positive and 31 said it did little⁹. Value drew 40 positive and 32 negative mentions, and 15 of 35 irritation mentions were negative⁹. On its own site it showed 4.9 from 437 reviews⁵. The brand runs that review system.

We could not load either store's Trustpilot page on 24 Oct 2026.

Safety and regulatory status

Both are sold as cosmetics, not medical devices, and neither page claims FDA approval^1,5. Medicube cites a South Korean listing: "Dual functionality for fine lines and brightening (South Korea Ministry of Food and Drug Safety)"¹. It also says the serum is "Dermatologist-tested" and "Tested to be Low-Irritating"¹. Those are brand claims.

Rejuran's page cites two studies of its own, both twice a day for 2 weeks⁵. One was run by the Korea Institute of Dermatological Science with 22 people, on healing after burns and treatments. The other was an in-house study with 1 volunteer⁵. Our PubMed search for Rejuran did not show them. The Rejuran studies it did show test an injected polynucleotide used in clinics, such as a 2026 trial of 25 women after radiofrequency treatment¹². Those results do not apply to a serum. A PubMed search for Medicube found no study of the serum¹³.

Rejuran's Amazon listing says to stop and see a specialist if red spots, swelling or itching appear, and not to apply it to wounds⁹. Medicube's salmon version and Rejuran's ampoule are salmon-based, so ask a doctor first if you have a fish allergy^1,9. See a dermatologist first if you are pregnant or treating a skin condition.

Verdict

Pick Medicube if price per mL matters most, or you want a vegan PDRN version. At $0.80 per mL, it costs less than half of Rejuran at full price^2,6. Its downsides are refunds for damaged items only and a "formulated without" list that clashes with its ingredients^1,3.

Pick Rejuran if you want a refund option on an unopened bottle, an ingredient list with no fragrance, or a subscription. Expect to pay $1.27 to $1.73 per mL on its own site, and a $10 fee on any refund^6,7. Its "highest level" claim has no number on its own site to back it⁵.

For how PDRN compares with other ingredients, see exosomes vs PDRN and copper peptides vs PDRN.

Last checked 24 Oct 2026.